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Alternative Splicing in the Human Genome and its Evolutionary Consequences

  1. Liliana Florea

Published Online: 15 JUL 2008

DOI: 10.1002/9780470015902.a0020746

eLS

eLS

How to Cite

Florea, L. 2008. Alternative Splicing in the Human Genome and its Evolutionary Consequences. eLS. .

Author Information

  1. George Washington University, Washington DC, USA

Publication History

  1. Published Online: 15 JUL 2008

Abstract

Alternative splicing, or the ability of genes to produce multiple messenger ribonucleic acid (mRNA) and protein isoforms by using different combinations of a gene's segments (exons), has recently been regarded as a mechanism that can explain how functional diversity in higher organisms can be achieved from a small number of genes, and thus can ultimately contribute to the increase in organism complexity during evolution.

Keywords:

  • alternative splicing;
  • evolution;
  • exons;
  • introns;
  • nonsense-mediated decay