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Evolution of Gene Expression in Human and Chimpanzee Brains

  1. Naoki Osada1,
  2. Sugano Sumio2,
  3. Yutaka Suzuki2

Published Online: 14 MAR 2008

DOI: 10.1002/9780470015902.a0020748

eLS

eLS

How to Cite

Osada, N., Sumio, S. and Suzuki, Y. 2008. Evolution of Gene Expression in Human and Chimpanzee Brains. eLS. .

Author Information

  1. 1

    National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan

  2. 2

    University of Tokyo, Tokyo, Japan

Publication History

  1. Published Online: 14 MAR 2008

This is not the most recent version of the article. View current version (15 APR 2013)

Abstract

The deoxyribonucleic acid (DNA) microarray technique enables us to gauge the difference in gene expression level between human and chimpanzee brains at a genome-wide level. Several studies have shown that (1) gene expression is more conservative in the brain than in other tissues, (2) the divergence rate of gene expression in the brain is higher in the lineage of humans than in the chimpanzees and (3) more genes are up-regulated in human brains.

Keywords:

  • evolution;
  • primates;
  • DNA microarray;
  • gene expression;
  • brain