Susceptibility to Human Infectious Diseases, Genetics of
Published Online: 30 APR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Kaslow, R. A., Shrestha, S. and Tang, J. ‘. 2008. Susceptibility to Human Infectious Diseases, Genetics of. eLS. .
- Published Online: 30 APR 2008
Microbial pathogens have shaped portions of the human genome over the millennia of its evolution, resulting in human genetic diversity and differential susceptibility to infectious diseases. Distinguishing characteristics of infectious diseases permit and require specific approaches to the investigation of genetic influences that can differ substantially from highly favourable to highly unfavourable. Expanding knowledge and improved technology are revealing important deoxyribonucleic acid (DNA) sequence and structural polymorphism in critical pathways of the innate and acquired immune systems. Reports are proliferating on relationships of responses to infection with variants of genes that encode secreted cytokines and lectins along with their receptors, intracellular signalling molecules, components of the antigen-presenting machinery and other effector or regulatory products. These notable accomplishments foreshadow both revelations and challenges in dissecting the complex host genetic mediation of differential responses to infectious diseases in individuals and populations.
- antigen presentation;
- genetic susceptibility;
- immune response;
- infectious disease;
- innate immunity;
- acquired immunity