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Evolution of Human Gene Expression Control

  1. Courtney C Babbitt,
  2. Gregory A Wray

Published Online: 14 MAR 2008

DOI: 10.1002/9780470015902.a0020769



How to Cite

Babbitt, C. C. and Wray, G. A. 2008. Evolution of Human Gene Expression Control. eLS. .

Author Information

  1. Duke University, Durham, North Carolina, USA

Publication History

  1. Published Online: 14 MAR 2008

This is not the most recent version of the article. View current version (17 FEB 2014)


The evolutionary history of Homo sapiens has been influenced by selection acting not only on coding regions of the genome, but also on regulatory sequences which control the timing, location and magnitude of gene expression. As the mutations affecting the timing and level of gene expression may be responsible for many of the traits that distinguish us from our closest relatives, selection on regulatory elements of the genome also may have had a large role in shaping recent human evolutionary change.


  • cis-regulation;
  • functional genomics;
  • human evolution;
  • gene expression;
  • polymorphism