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Human and Macaque Transcriptomes: A Comparison

  1. Stephen J Walker

Published Online: 15 JUL 2008

DOI: 10.1002/9780470015902.a0020771

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How to Cite

Walker, S. J. 2008. Human and Macaque Transcriptomes: A Comparison. eLS. .

Author Information

  1. Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA

Publication History

  1. Published Online: 15 JUL 2008

Abstract

The initial deciphering of entire genomes from several mammalian species including human, chimpanzee and macaque has now been accomplished and the massive datasets are publicly available in the form of high-quality draft sequences. As a direct result, the development and commercialization of an ever-increasing number of sensitive tools to measure global gene expression (the ‘transcriptome’) is providing unique opportunities to evaluate and compare biological systems. One particularly important application is to use tissues derived from macaque models of toxicity and disease to infer responses in their human counterparts. Understanding the similarities and differences in how macaques and humans respond, at the functional genomic level, to perturbations in their environments has significant relevance in biomedical research.

Keywords:

  • macaque;
  • microarray;
  • transcriptome;
  • gene expression;
  • genome