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Transcription Factor-binding Sites: Recent Evolution in the Human Lineage

  1. Berthold Göttgens

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0020774

eLS

eLS

How to Cite

Göttgens, B. 2007. Transcription Factor-binding Sites: Recent Evolution in the Human Lineage. eLS. .

Author Information

  1. University of Cambridge, Cambridge, UK

Publication History

  1. Published Online: 21 DEC 2007

Abstract

Alteration in transcriptional regulatory mechanisms represents an important platform for evolutionary change yet relatively little is known about the extent to which evolution of transcriptional control mechanisms has contributed to recent human evolution. Recent computational analysis suggests that a significant proportion of functional human–chimpanzee sequence differences may affect regulatory elements thus opening up a fruitful avenue for future research to identify pathways underlying recent human evolution and diversity as well as disease predisposition.

Keywords:

  • transcription;
  • binding sites;
  • human evolution;
  • gene regulation