Transcription Factor-binding Sites: Recent Evolution in the Human Lineage
Published Online: 21 DEC 2007
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Göttgens, B. 2007. Transcription Factor-binding Sites: Recent Evolution in the Human Lineage. eLS. .
- Published Online: 21 DEC 2007
Alteration in transcriptional regulatory mechanisms represents an important platform for evolutionary change yet relatively little is known about the extent to which evolution of transcriptional control mechanisms has contributed to recent human evolution. Recent computational analysis suggests that a significant proportion of functional human–chimpanzee sequence differences may affect regulatory elements thus opening up a fruitful avenue for future research to identify pathways underlying recent human evolution and diversity as well as disease predisposition.
- binding sites;
- human evolution;
- gene regulation