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Bidirectional Gene Pairs in the Human Genome

  1. Kanako O Koyanagi1,
  2. Tadashi Imanishi2,
  3. Takashi Gojobori3

Published Online: 15 JUL 2008

DOI: 10.1002/9780470015902.a0020776



How to Cite

Koyanagi, K. O., Imanishi, T. and Gojobori, T. 2008. Bidirectional Gene Pairs in the Human Genome. eLS. .

Author Information

  1. 1

    Hokkaido University, Sapporo, Hokkaido, Japan

  2. 2

    AIST, Koto-ku, Tokyo, Japan

  3. 3

    National Institute of Genetics, Mishima, Shizuoka, Japan

Publication History

  1. Published Online: 15 JUL 2008

This is not the most recent version of the article. View current version (8 DEC 2013)


Bidirectional gene pairs, also called head-to-head gene pairs, are defined as two genes on different strands with adjacent 5′-ends. They are transcribed divergently in a variety of coordinated fashion. The region between two transcription start sites of a bidirectional gene pair is designated as a putative bidirectional promoter.


  • genome organization;
  • coexpression;
  • promoter