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Dual-coding Regions in Alternatively Spliced Human Genes

  1. Han Liang1,
  2. Laura F Landweber2

Published Online: 14 MAR 2008

DOI: 10.1002/9780470015902.a0020780

eLS

eLS

How to Cite

Liang, H. and Landweber, L. F. 2008. Dual-coding Regions in Alternatively Spliced Human Genes. eLS. .

Author Information

  1. 1

    University of Chicago, Department of Ecology and Evolution, Chicago, Illinois, USA

  2. 2

    Princeton University, Department of Ecology and Evolutionary Biology, Princeton, New Jersey, USA

Publication History

  1. Published Online: 14 MAR 2008

This is not the most recent version of the article. View current version (15 APR 2013)

Abstract

By using different exon combinations, alternatively spliced genes may contain dual-coding regions, where more than one reading frame encodes amino acid sequences. These special coding regions generate functionally related but distinct protein products and evolve under unusual selective forces.

Keywords:

  • alternative splicing;
  • reading frame;
  • in-frame stop;
  • overlapping genes