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Evolutionary Conservation of Splice Sites

  1. Michelle L. Hastings1,
  2. Ravi Sachidanandam2

Published Online: 30 APR 2008

DOI: 10.1002/9780470015902.a0020782



How to Cite

Hastings, M. L. and Sachidanandam, R. 2008. Evolutionary Conservation of Splice Sites. eLS. .

Author Information

  1. 1

    Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA

  2. 2

    Cold Spring Harbor Laboratory, New York, USA

Publication History

  1. Published Online: 30 APR 2008


The evolution of splice sites (both 5′ and 3′) is constrained. The results of the constraints are observed in conserved signatures exhibited by splice sites across species.


  • splice sites;
  • pre-mRNA splicing;
  • evolution;
  • spliceosome;
  • acceptor;
  • donor