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Evolutionary Conservation of Splice Sites

  1. Michelle L. Hastings1,
  2. Ravi Sachidanandam2

Published Online: 30 APR 2008

DOI: 10.1002/9780470015902.a0020782

eLS

eLS

How to Cite

Hastings, M. L. and Sachidanandam, R. 2008. Evolutionary Conservation of Splice Sites. eLS. .

Author Information

  1. 1

    Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA

  2. 2

    Cold Spring Harbor Laboratory, New York, USA

Publication History

  1. Published Online: 30 APR 2008

Abstract

The evolution of splice sites (both 5′ and 3′) is constrained. The results of the constraints are observed in conserved signatures exhibited by splice sites across species.

Keywords:

  • splice sites;
  • pre-mRNA splicing;
  • evolution;
  • spliceosome;
  • acceptor;
  • donor