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MicroRNA Evolution in the Human Genome

  1. Bing Su,
  2. Rui Zhang

Published Online: 14 MAR 2008

DOI: 10.1002/9780470015902.a0020788

eLS

eLS

How to Cite

Su, B. and Zhang, R. 2008. MicroRNA Evolution in the Human Genome. eLS. .

Author Information

  1. Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China

Publication History

  1. Published Online: 14 MAR 2008

Abstract

Micro ribonucleic acids (miRNAs) are a growing class of small RNA [∼22 nucleotide (nt)] that function as negative regulators in the genome by targeting messenger RNA (mRNA) for translational repression, cleavage and destabilization. Hundreds of miRNAs have been identified in the human genome. miRNAs can be conserved or nonconserved according to their cross-species sequence conservation, and these two classes of miRNAs in the human genome are subject to distinct evolutionary patterns.

Keywords:

  • miRNA;
  • evolution;
  • human genome