MicroRNA Evolution in the Human Genome
Published Online: 14 MAR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Su, B. and Zhang, R. 2008. MicroRNA Evolution in the Human Genome. eLS. .
- Published Online: 14 MAR 2008
Micro ribonucleic acids (miRNAs) are a growing class of small RNA [∼22 nucleotide (nt)] that function as negative regulators in the genome by targeting messenger RNA (mRNA) for translational repression, cleavage and destabilization. Hundreds of miRNAs have been identified in the human genome. miRNAs can be conserved or nonconserved according to their cross-species sequence conservation, and these two classes of miRNAs in the human genome are subject to distinct evolutionary patterns.
- human genome