Positive Selection and the Evolution of Prodynorphin
Published Online: 14 MAR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Rockman, M. V. 2008. Positive Selection and the Evolution of Prodynorphin. eLS. .
- Published Online: 14 MAR 2008
Positive natural selection has shaped the cis-regulation of human prodynorphin, the precursor molecule for a suite of opioid neuropeptides with roles in perception. Population genetic data suggest that after the split between the human and chimpanzee lineages, selection drove multiple substitutions in a regulatory element upstream of prodynorphin. The substitutions fall within a cis-regulatory tandem repeat polymorphism segregating in contemporary populations. The repeat polymorphism is also seen by selection, and differing repeat allele frequencies in different parts of the globe reflect the varying pattern of positive selection.
- positive selection;
- evolutionary genetics;