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The Contribution of Frameshift Translation to the Generation of Novel Human Proteins

  1. Kohji Okamura,
  2. Stephen W Scherer

Published Online: 21 DEC 2007

DOI: 10.1002/9780470015902.a0020792

eLS

eLS

How to Cite

Okamura, K. and Scherer, S. W. 2007. The Contribution of Frameshift Translation to the Generation of Novel Human Proteins. eLS. .

Author Information

  1. The Hospital for Sick Children, Toronto, Canada

Publication History

  1. Published Online: 21 DEC 2007

Abstract

The creation of novel proteins is not simply ascribed to duplication of homologous sequences, but can be largely explained by frameshift translation. A deficiency of the TpA dinucleotide in protein-coding deoxyribonucleic acid (DNA) sequences renders them tolerant of frameshift mutations by minimizing the opportunity for premature stop codons, and involvement of both strands can increase genomic complexity. This supports the suggestion that new coding sequences evolve from existing or ancestral exons rather than from nonexonic sequences.

Keywords:

  • protein-coding sequence;
  • frameshift;
  • TpA dinucleotide;
  • termination codon;
  • intrastrand parity in DNA