An Evolutionary Genetic Framework for Heritable Disorders
Published Online: 15 JUL 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Keller, M. C. 2008. An Evolutionary Genetic Framework for Heritable Disorders. eLS. .
- Published Online: 15 JUL 2008
Natural selection is expected to drive the frequencies of heritable, fitness-harming states to very low levels, yet many heritable disorders – and especially mental disorder – are common in the human population. These two statements are sometimes interpreted to imply that disorders have not been under natural selection, but this need not be the case. Evolutionary genetics provides three broad classes of models, none of them mutually exclusive, for understanding why disorder risk alleles have persisted in the human population despite natural selection.
- mental disorders;