The Biological Significance of Conserved Nongenic DNA
Published Online: 15 JUL 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Dermitzakis, E. T. 2008. The Biological Significance of Conserved Nongenic DNA. eLS. .
- Published Online: 15 JUL 2008
Although the completion of the human genome was a landmark in genomics, the availability of a single genome did not offer the opportunity to detect most of the functional part of the genome. With the completion of the mouse genome and the subsequent release of additional mammalian and other vertebrate genomes, a large number of conserved nonprotein-coding sequences were discovered. The most surprising discovery was that the nongenic fraction of the genome that is under purifying selection is larger than the coding fraction of the genome. In this article we review some of the key discoveries in the field and discuss methodologies for the computational and functional interpretation of nongenic deoxyribonucleic acid (DNA).
- comparative genomics;
- non-coding DNA