Biased Gene Conversion and its Impact on Human Genome Evolution
Published Online: 14 MAR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Galtier, N. and Duret, L. 2008. Biased Gene Conversion and its Impact on Human Genome Evolution. eLS.
- Published Online: 14 MAR 2008
Gene conversion between the maternal and paternal alleles occurs during meiosis as part of the complex molecular process of homologous recombination. Consequently, the transmission of alleles can be non-Mendelian for loci located near recombination initiation sites. A large body of evidence suggests that such events of meiotic gene conversion are GC-biased: AT/GC heterozygotes produce an elevated proportion of GC gametes, resulting in an evolutionary advantage for GC over AT alleles. This neutral biased gene conversion (BGC) process has surprisingly strong consequences on the evolution of genomic landscapes in human.
- substitution rate;
- DNA repair