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Pseudogene Evolution in the Human Genome

  1. Zhaolei Zhang1,
  2. Deyou Zheng2

Published Online: 30 APR 2008

DOI: 10.1002/9780470015902.a0020836



How to Cite

Zhang, Z. and Zheng, D. 2008. Pseudogene Evolution in the Human Genome. eLS. .

Author Information

  1. 1

    University of Toronto, Toronto, Ontario, Canada

  2. 2

    Rose F. Kennedy Center, New York, USA

Publication History

  1. Published Online: 30 APR 2008

This is not the most recent version of the article. View current version (17 FEB 2014)


Pseudogenes are those regions in the genome that have sequence similarity to functional genes but have decayed and do not have obvious functions. It is estimated that the human genome contain more than 10 000 easily recognizable pseudogenes and many more fragmented sequences, mainly arose through one of the following three mechanisms: duplication, retrotranposition and spontaneous loss of function.


  • pseudogene;
  • human genome;
  • retrotransposition;
  • evolution;
  • comparative genomics