Simple Sequence Repeats in the Human Genome: Evolution
Published Online: 30 APR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Riley, D. E. and Krieger, J. N. 2008. Simple Sequence Repeats in the Human Genome: Evolution. eLS. .
- Published Online: 30 APR 2008
Recent evolutionary findings suggest important functions for even-numbered, simple sequence repeats (SRs). During evolution, weak-folding SRs whose single-stranded forms were incapable of forming classically paired duplex stems, replaced other weak-folding repeats. Strong-folding repeats replaced other strong-folding repeats. Among untranslated regions, SRs were associated with genes encoding membrane-related functions and genes encoding transcription factors. Among all possible SR sequences, evolution selected primarily weak-folding repeats. The evolution of many of the differences comparing human SR usage with other mammals can now be mapped using publically available genome sequences. Human SR sites evolved by a variety of pathways.
- single stranded;
- species differences;