Ultraconserved DNA Sequence Elements in the Human Genome
Published Online: 30 APR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Lee, A. P. and Venkatesh, B. 2008. Ultraconserved DNA Sequence Elements in the Human Genome. eLS. .
- Published Online: 30 APR 2008
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Ultraconserved elements are deoxyribonucleic acid (DNA) sequences at least 200 base pairs in length and perfectly conserved in human, mouse and rat genomes. These elements are under extreme purifying selection and are implicated in functions such as transcriptional enhancers, exons of noncoding ribonucleic acid (RNA) transcripts and alternatively spliced ‘poison cassette exons’ that regulate the expression of certain classes of proteins.
- ultraconserved element;
- human genome;
- purifying selection;
- transcriptional enhancer