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Human-specific Accelerated Evolution of Noncoding Sequences

  1. Matthew T Webster

Published Online: 30 APR 2008

DOI: 10.1002/9780470015902.a0020849

eLS

eLS

How to Cite

Webster, M. T. 2008. Human-specific Accelerated Evolution of Noncoding Sequences. eLS. .

Author Information

  1. Uppsala University, Uppsala, Sweden

Publication History

  1. Published Online: 30 APR 2008

This is not the most recent version of the article. View current version (15 APR 2013)

Abstract

Mutations in noncoding elements that regulate gene expression are likely to be responsible for a large fraction of phenotypic evolution. Hundreds of putative regulatory elements have been identified with accelerated evolutionary rates in the human lineage, which could be involved in human-specific adaptations. However, instead of being driven by natural selection, the elevated rates of sequence evolution appear to be largely governed by neutral processes.

Keywords:

  • human evolution;
  • noncoding DNA;
  • natural selection;
  • gene regulation;
  • recombination