Identifying Regions of the Human Genome that Exhibit Evidence for Positive Selection
Published Online: 15 JUL 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Kimura, R. and Ohashi, J. 2008. Identifying Regions of the Human Genome that Exhibit Evidence for Positive Selection. eLS. .
- Published Online: 15 JUL 2008
This is not the most recent version of the article. View current version (15 NOV 2013)
The recent availability of human genomic data has driven genome-wide scans for natural selection with different approaches based on comparative genetics and population genetics. Such studies have provided many candidates for targets of positive selection in the human genome, but the results should be interpreted with caution because of the inevitability of false positives. Here, approaches for identifying positive selection in the human genome are reviewed, and, especially, an up-to-date approach based on haplotype variation and linkage disequilibrium is explained in detail.
- positive selection;
- human genome;
- selective sweep;
- haplotype variation