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Selection against Amino Acid Replacements in Human Proteins

  1. Sankar Subramanian

Published Online: 14 MAR 2008

DOI: 10.1002/9780470015902.a0020859

eLS

eLS

How to Cite

Subramanian, S. 2008. Selection against Amino Acid Replacements in Human Proteins. eLS. .

Author Information

  1. Massey University, Auckland, New Zealand

Publication History

  1. Published Online: 14 MAR 2008

This is not the most recent version of the article. View current version (15 MAR 2013)

Abstract

The similarity of a large fraction of amino acid residues of human protein sequences with that of other species implies that the mutations altering those amino acids were purged through natural selection during the evolution of the human lineage. The deleterious effect of amino acid replacement mutations in human population is manifested by the association of many of these with genetic diseases.

Keywords:

  • natural selection;
  • protein evolution;
  • human genetics;
  • disease-associated mutations