Modelling Cancer in Drosophila
Published Online: 14 MAR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Brumby, A. M. and Richardson, H. E. 2008. Modelling Cancer in Drosophila. eLS. .
- Published Online: 14 MAR 2008
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Ever since the discovery of neoplastic and metastatic overgrowths in Drosophila melanogaster, the fly has been recognized as an excellent model organism for studying tumorigenesis. Recently, however, its relevance has become even more pronounced with the modelling of neoplasias in somatic clones of tissue using cooperative interactions between tumour suppressors and homologues of known mammalian oncogenes. The realization that many Drosophila neoplasias can be understood with respect to aberrant differentiation of stem cell progeny, together with the growing trend to postulate a stem cell origin of mammalian cancers, further highlight the enormous potential of fly cancer models to greatly increase our understanding of how human cancers develop.
- stem cells;