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MicroRNAs in Development and Disease

  1. Alison A Staton,
  2. Antonio J Giraldez

Published Online: 15 JUL 2008

DOI: 10.1002/9780470015902.a0020863

eLS

eLS

How to Cite

Staton, A. A. and Giraldez, A. J. 2008. MicroRNAs in Development and Disease. eLS. .

Author Information

  1. Yale University School of Medicine, New Haven, Connecticut, USA

Publication History

  1. Published Online: 15 JUL 2008

Abstract

Micro ribonucleic acids (miRNAs) are small RNAs responsible for selective repression and degradation of mRNAs. Regulation by miRNAs during development facilitates the transition from one stage to the next and can control specialized characteristics of mature cells. When this regulation is disrupted, cancer can result through increases in proliferation and defects in differentiation.

Keywords:

  • microRNA;
  • Dicer;
  • development;
  • developmental transition