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Genetic Analysis of Hybrid Incompatibilities in Drosophila

  1. Pierre R Gérard,
  2. Daven C Presgraves

Published Online: 15 MAR 2009

DOI: 10.1002/9780470015902.a0020896



How to Cite

Gérard, P. R. and Presgraves, D. C. 2009. Genetic Analysis of Hybrid Incompatibilities in Drosophila. eLS. .

Author Information

  1. University of Rochester, Rochester, New York, USA

Publication History

  1. Published Online: 15 MAR 2009

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New species evolve when previously interbreeding populations diverge from one another and, as an incidental byproduct, accumulate reproductive barriers such as hybrid sterility and inviability. Fine-scale genetic analyses show that the X-chromosome plays a special role in the evolution of hybrid sterility, and molecular analyses show that the genes causing hybrid sterility and inviability usually diverge between species by positive natural selection.


  • speciation;
  • postzygotic isolation;
  • Haldane's rule;
  • hybrid inviability;
  • hybrid sterility