Evolutionary History and Impact of Human DNA Transposons
Published Online: 14 MAR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Feschotte, C. 2008. Evolutionary History and Impact of Human DNA Transposons. eLS. .
- Published Online: 14 MAR 2008
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Deoxyribonucleic acid (DNA) transposons are mobile elements that move via a DNA intermediate. The human genome harbours over 300 000 DNA transposon copies, accounting for approximately 3% of the total genomic DNA. Nearly one-third of these elements are specific to the primate lineage, but there is no evidence for transposition activity within the last 40 million years. However, there is growing evidence that DNA transposons have contributed in shaping the current genome architecture of humans and have been a recurrent source of new regulatory and coding DNA throughout mammalian evolution.
- transposable elements;
- selfish DNA;
- noncoding DNA;
- new genes;
- genome evolution