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Chromatin Structure and Human Genome Evolution

  1. Colin AM Semple

Published Online: 30 APR 2008

DOI: 10.1002/9780470015902.a0020999



How to Cite

Semple, C. A. 2008. Chromatin Structure and Human Genome Evolution. eLS. .

Author Information

  1. MRC Human Genetics Unit, Edinburgh, UK

Publication History

  1. Published Online: 30 APR 2008

This is not the most recent version of the article. View current version (13 JUN 2013)


Functional and comparative genomics have provided data on the evolution and function of the human genome, but we still know relatively little about its spatial organization. What is the three-dimensional structure of the genome? How and when does this structure vary? It has long been suspected that the structural organization of the genome might impose constraints on its evolution. Recent genome-wide data on chromatin structure have revealed the complex physical landscape of the human genome, and have yielded unexpected insights into the evolution of chromosome architecture, gene order and patterns of mutation and selection.


  • evolution;
  • chromatin structure;
  • human;
  • epigenetics