Processed Pseudogenes and Their Functional Resurrection in the Human and Mouse Genomes
Published Online: 15 JUL 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Sakai, H., Itoh, T. and Gojobori, T. 2008. Processed Pseudogenes and Their Functional Resurrection in the Human and Mouse Genomes. eLS. .
- Published Online: 15 JUL 2008
The genomes of human and mouse contain thousands of pseudogenes. Processed pseudogenes, which were derived through retrotransposition, were recognized as ‘dead on arrival’ elements in the genomes, and they have been thought to have no contribution to genome evolution. However, several recent studies have shown that a significant portion of processed pseudogenes were transcribed and were able to function as noncoding ribonucleic acid (RNA) genes. Since the transcription mechanism and functions of transcribed processed pseudogenes still remain unknown, it is of great importance to elucidate the biological roles of processed pseudogenes by both approaches of experiments and bioinformatics.
- retrotransposed copy;
- processed pseudogene;