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Processed Pseudogenes and Their Functional Resurrection in the Human and Mouse Genomes

  1. Hiroaki Sakai1,
  2. Takeshi Itoh1,
  3. Takashi Gojobori2

Published Online: 15 JUL 2008

DOI: 10.1002/9780470015902.a0021000

eLS

eLS

How to Cite

Sakai, H., Itoh, T. and Gojobori, T. 2008. Processed Pseudogenes and Their Functional Resurrection in the Human and Mouse Genomes. eLS. .

Author Information

  1. 1

    National Institute of Agrobiological Sciences, Tsukuba, Japan

  2. 2

    National Institute of Genetics, Mishima, Japan

Publication History

  1. Published Online: 15 JUL 2008

Abstract

The genomes of human and mouse contain thousands of pseudogenes. Processed pseudogenes, which were derived through retrotransposition, were recognized as ‘dead on arrival’ elements in the genomes, and they have been thought to have no contribution to genome evolution. However, several recent studies have shown that a significant portion of processed pseudogenes were transcribed and were able to function as noncoding ribonucleic acid (RNA) genes. Since the transcription mechanism and functions of transcribed processed pseudogenes still remain unknown, it is of great importance to elucidate the biological roles of processed pseudogenes by both approaches of experiments and bioinformatics.

Keywords:

  • retrotransposition;
  • retrotransposed copy;
  • retrogene;
  • processed pseudogene;
  • transcription