Standard Article

Comparing the Human and Fish Genomes

  1. Yoichiro Nakatani,
  2. Shinichi Morishita

Published Online: 30 APR 2008

DOI: 10.1002/9780470015902.a0021004



How to Cite

Nakatani, Y. and Morishita, S. 2008. Comparing the Human and Fish Genomes. eLS. .

Author Information

  1. University of Tokyo, Kashiwa, Chiba, Japan

Publication History

  1. Published Online: 30 APR 2008

This is not the most recent version of the article. View current version (20 SEP 2013)


How have the genomes of vertebrates evolved over the last 600 million years? In 1970, based on limited observations, Ohno postulated that whole genome duplication events took place in early vertebrates and were essential to increasing complexity of vertebrates. This issue, however, remains a biological quandary. Recent rapid progress in sequencing the genomes of many vertebrates has revealed fundamental insights into the evolutionary process, and the comparative genomics of the fish and human genomes is indispensable for providing conclusive support to Ohno's hypothesis.


  • comparative genomics;
  • chromosome evolution;
  • vertebrate genomes