Macrophages in Lipid and Immune Homeostasis
Published Online: 15 DEC 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Neyen, C. D. and Gordon, S. 2008. Macrophages in Lipid and Immune Homeostasis. eLS. .
- Published Online: 15 DEC 2008
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Many components of the immune system play diverse roles in lipid metabolism and vice versa. Macrophage immune functions, including pathogen clearance and apoptotic cell removal, are regulated by lipids but also generate effectors that impact on lipid homeostasis. Oxidized lipids, byproducts of the oxidative burst, activate nuclear receptors, which not only orchestrate lipid homeostasis but also cross-regulate NFκB-driven immune responses. Activation of macrophages leads to cytokine production and induction of the acute phase response, accompanied by systemic lipid changes. Lipoproteins and their components, as well as lipid transport molecules, are emerging as novel actors in innate immune defence.
- innate immunity;
- nuclear receptor(s);
- oxidized lipid(s)