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Macrophages in Lipid and Immune Homeostasis

  1. Claudine D Neyen,
  2. Siamon Gordon

Published Online: 15 DEC 2008

DOI: 10.1002/9780470015902.a0021029

eLS

eLS

How to Cite

Neyen, C. D. and Gordon, S. 2008. Macrophages in Lipid and Immune Homeostasis. eLS. .

Author Information

  1. Oxford University, Sir William Dunn School of Pathology, Oxford, UK

Publication History

  1. Published Online: 15 DEC 2008

This is not the most recent version of the article. View current version (15 JUL 2014)

Abstract

Many components of the immune system play diverse roles in lipid metabolism and vice versa. Macrophage immune functions, including pathogen clearance and apoptotic cell removal, are regulated by lipids but also generate effectors that impact on lipid homeostasis. Oxidized lipids, byproducts of the oxidative burst, activate nuclear receptors, which not only orchestrate lipid homeostasis but also cross-regulate NFκB-driven immune responses. Activation of macrophages leads to cytokine production and induction of the acute phase response, accompanied by systemic lipid changes. Lipoproteins and their components, as well as lipid transport molecules, are emerging as novel actors in innate immune defence.

Keywords:

  • macrophage;
  • innate immunity;
  • lipoprotein(s);
  • nuclear receptor(s);
  • oxidized lipid(s)