Biomolecular NMR Spectroscopy of Ribonucleic Acids
Published Online: 30 APR 2008
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Dieckmann, T. and Legault, P. 2008. Biomolecular NMR Spectroscopy of Ribonucleic Acids. eLS. .
- Published Online: 30 APR 2008
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Biomolecular nuclear magnetic resonance (NMR) spectroscopy allows the characterization of structural and dynamic properties of ribonucleic acids (RNAs) in solution. The NMR-based determination of high-resolution three-dimensional (3D) structures has been achieved for RNAs up to ca. 100 nucleotides. Biomolecular NMR also provides valuable information about RNA–ligand interactions and the role of metal ions and shifted pKa in RNA structure and catalysis.
- RNA structure;
- isotope labelling;
- molecular dynamics;
- metal ion binding