Evolution of the p53 and p63/p73 Gene Families
Published Online: 15 SEP 2009
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Pintus, S. S. 2009. Evolution of the p53 and p63/p73 Gene Families. eLS. .
- Published Online: 15 SEP 2009
The tumour suppressor protein p53 is one of the most studied eukaryote proteins. The finding of its paralogues – p63 and p73 – inspired investigations of the whole family. p73 and p63 appeared to have functions distinct from p53 and to be involved in complex regulation of the latter. Evolutionary studies revealed distant homologues of the family not only in vertebrates but also in protostomes and even in nonmetazoans. The evolutionary history of the p53 family and its relatives is complex, controversial and its intensive study goes on.
The p53 and p63/p73 gene families evolve from the common p63-like ancestor via specialization through gene duplications and domain gains and losses.