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Molecular Evolution of The Keratin-associated Protein Gene Family

  1. Dong-Dong Wu,
  2. Ya-Ping Zhang

Published Online: 15 SEP 2009

DOI: 10.1002/9780470015902.a0021767

eLS

eLS

How to Cite

Wu, D.-D. and Zhang, Y.-P. 2009. Molecular Evolution of The Keratin-associated Protein Gene Family. eLS. .

Author Information

  1. Kunming Institute of Zoology, Chinese Academy of Sciences, Beijing, China

Publication History

  1. Published Online: 15 SEP 2009

Abstract

Hair, unique to mammals, plays a profound role in the heat retention within homoiotherms and presumably contributes significantly to the rapid radiation of mammals to become the dominant terrestrial vertebrate on earth. Keratin-associated protein (KRTAP) is one of the major component of hair. Phylogenetic analysis of the KRTAP gene family could illuminate the origin and evolution of mammalian hair to some extent. Furthermore, study of KRTAP gene family will provide important information on the hair-related disorders.

Key concepts

  • KRTAP is one of the major components of mammalian hair. To some extent, a relation lies between the molecular evolution of KRTAP gene family and evolution of hair. Comparative genomic and polymorphism data of the KRTAP gene family will provide important information on the hair disorders in the human populations.

Keywords:

  • keratin-associated protein;
  • KRTAP;
  • gene family;
  • molecular evolution