Uniparental Disomy in Cancer – A New Tool in Molecular Cancer
Published Online: 19 MAY 2010
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Tuna, M. and Amos, C. I. 2010. Uniparental Disomy in Cancer – A New Tool in Molecular Cancer. eLS. .
- Published Online: 19 MAY 2010
The cancer genome project has attempted to provide the complete landscape of existing mutations in tumours, but sequencing the whole genome for all tumour types is a challenging goal. Recently a novel form of abnormality in various cancers, acquired uniparental disomy (aUPD), has been revealed. aUPD regions may pinpoint the mutated genes for next generation sequencing. Therefore, identifying the aUPD regions can help to identify novel candidate genes for mutation analysis instead of randomly sequencing the genome, may help to distinguish driver genes from passenger, lead to the discovery of novel therapeutic targets and provide important prognostic information, which may thus lead to important clinical applications.
Acquired uniparental disomy is a novel form of abnormality in cancer.
The regions of acquired uniparental disomy pinpoint homozygously mutated or methylated genes.
Homozygously mutated genes in aUPD regions may be tumour-suppressor or oncogenes.
Homozygously mutated genes in aUPD regions may be involved in tumourigenesis.
aUPD regions may correlate with outcome of disease, so can be of use as prognostic marker.
- acquired uniparental disomy;
- solid tumours;
- myeloproliferative neoplasia;