Standard Article

Mitotic Spindle Assembly: The Role of Motor Proteins

  1. Janel Titus,
  2. Patricia Wadsworth

Published Online: 16 JUL 2012

DOI: 10.1002/9780470015902.a0022519

eLS

eLS

How to Cite

Titus, J. and Wadsworth, P. 2012. Mitotic Spindle Assembly: The Role of Motor Proteins. eLS. .

Author Information

  1. University of Massachusetts, Amherst, Massachusetts, USA

Publication History

  1. Published Online: 16 JUL 2012

Abstract

The mitotic spindle, a microtubule-based structure, is required for chromosome segregation during cell division. Motor proteins are molecular machines that utilise the energy of adenosine triphosphate (ATP) hydrolysis to move along microtubules. During cell division, motor proteins are required for spindle formation, chromosome alignment and segregation. Thus, mitotic motor proteins are required for the cell to avoid aneuploidy, a hallmark of cancer.

Key Concepts:

  • Molecular motors, including dynein/dynactin and several families of kinesin, are required for mitosis.

  • Kinesins contribute to establishing spindle bipolarity, positioning chromosomes between spindle poles and focusing spindle poles.

  • Dynein contributes to the metaphase checkpoint, spindle positioning, regulating spindle length and pole focusing.

  • To establish and maintain a mitotic spindle, motor proteins achieve a balance of forces on microtubules.

Keywords:

  • Mitosis;
  • kinesin;
  • dynein;
  • spindle;
  • spindle assembly;
  • motor protein;
  • microtubule;
  • ATP hydrolysis