Mitotic Spindle Assembly: The Role of Motor Proteins
Published Online: 16 JUL 2012
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Titus, J. and Wadsworth, P. 2012. Mitotic Spindle Assembly: The Role of Motor Proteins. eLS. .
- Published Online: 16 JUL 2012
The mitotic spindle, a microtubule-based structure, is required for chromosome segregation during cell division. Motor proteins are molecular machines that utilise the energy of adenosine triphosphate (ATP) hydrolysis to move along microtubules. During cell division, motor proteins are required for spindle formation, chromosome alignment and segregation. Thus, mitotic motor proteins are required for the cell to avoid aneuploidy, a hallmark of cancer.
Molecular motors, including dynein/dynactin and several families of kinesin, are required for mitosis.
Kinesins contribute to establishing spindle bipolarity, positioning chromosomes between spindle poles and focusing spindle poles.
Dynein contributes to the metaphase checkpoint, spindle positioning, regulating spindle length and pole focusing.
To establish and maintain a mitotic spindle, motor proteins achieve a balance of forces on microtubules.
- spindle assembly;
- motor protein;
- ATP hydrolysis