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Trypsin-like Serine Proteases and the Evolution of Hematophagy in Mosquitoes

  1. Dong-Dong Wu,
  2. Ya-Ping Zhang

Published Online: 17 JAN 2011

DOI: 10.1002/9780470015902.a0022880

eLS

eLS

How to Cite

Wu, D.-D. and Zhang, Y.-P. 2011. Trypsin-like Serine Proteases and the Evolution of Hematophagy in Mosquitoes. eLS. .

Author Information

  1. Kunming Institute of Zoology, Chinese Academy of Sciences, Beijing, China

Publication History

  1. Published Online: 17 JAN 2011

Abstract

Mosquitoes are scourge of humanity because they transmit many diseases during blood sucking. Study on the genes associated with the process of hematophagy will be helpful for studying and controlling mosquito-borne diseases. Trypsin-like serine protease family is ubiquitous and evolves dynamically in animals, and plays an important role in the digestion of food. The gene family is expanded significantly in the mosquito genomes, and the expression level of these genes is elevated remarkably after blood meal, particularly these phylogenetically expanded genes. Positive Darwinian selection is considered to drive the evolution and diversification of trypsin-like serine protease family, which probably contributes profoundly to the hematophagous trait in mosquitoes. The trypsin-like serine proteases are potential good candidates to study the process of hematophagy in mosquitoes and the control of mosquito-borne diseases.

Key Concepts:

  • Mosquitoes are scourge of humanity because they transmit many diseases.

  • Trypsin-like serine protease family plays an important role in the food digestion, and is expanded in the mosquito genomes.

  • The expression level of genes in the family is elevated remarkably after blood meal in mosquito, particularly these phylogenetically expanded genes.

  • Therefore, the expansion of trypsin-like serine protease family plays an important role in the evolution of hematophagy in mosquito.

Keywords:

  • trypsin-like serine protease;
  • evolution;
  • hematophagy;
  • mosquito;
  • positive selection;
  • phylogenetic