Evolution of Vault RNAs
Published Online: 15 FEB 2011
Copyright © 2001 John Wiley & Sons, Ltd. All rights reserved.
How to Cite
Mosig, A. and Stadler, P. F. 2011. Evolution of Vault RNAs. eLS. .
- Published Online: 15 FEB 2011
Vault ribonucleic acids (RNAs) are small, about 100 nt long, polymerase transcripts contained in the vault particles of eukaryotic cells. Although vaults are present in many but by no means all eukaryotes, an RNA component has been described in metazoa only. The RNAs exhibit conserved regions at the 3′ and 5′ ends containing also internal promoter elements. They form a panhandle-like well-conserved secondary structure. Most genomes contain only one or a small number of closely related vault RNA sequences. Only eutheria exhibit two clearly distinguished paralogues at syntenically conserved genomic locations. Their phylogenetic distribution is characterised by losses in major clades, whereas lophotrochozoa have vault particles and vault RNAs, and the entire system has been deleted in all ecdysozoa.
Vault RNA can be traced evolutionarily along with the vault particle and its key protein components, most notably MVP.
Vault RNA exhibits a concserved pan-handle secondary structure and expression patterns that are often mistaken as a microRNA.
- RNA secondary structure;
- animal genomes;
- polymerase III transcripts