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Dayhoff, Margaret Oakley

  1. Bruno J Strasser

Published Online: 17 SEP 2012

DOI: 10.1002/9780470015902.a0023939

eLS

eLS

How to Cite

Strasser, B. J. 2012. Dayhoff, Margaret Oakley. eLS. .

Author Information

  1. University of Geneva, IUFE, Geneva, Switzerland

Publication History

  1. Published Online: 17 SEP 2012

Abstract

The American physical chemist Margaret Oakley Dayhoff was one of the major figures in the early history of bioinformatics. In 1965, she published the initial edition of the Atlas of Protein Sequence and Structure, the first comprehensive, computerised and publicly available collection of protein sequences. It became a model for many subsequent sequence databases, including GenBank. Dayhoff developed several methods to analyse protein sequences and infer their evolutionary relationships, as well as computer models to simulate the composition of planetary atmospheres.

Key Concepts:

  • Margaret O. Dayhoff was one of the founders in the field of bioinformatics.

  • Margaret O. Dayhoff created the first public comprehensive, computerised and publicly available database of protein sequences, The Atlas of Protein Sequence and Structure (1965).

  • The Atlas of Protein Sequence and Structure was the model for GenBank and many other molecular databases.

  • The Atlas of Protein Sequence and Structure was a key tool for the development of molecular biology, molecular evolution and bioinformatics.

  • The Atlas of Protein Sequence and Structure was tremendously successful among researchers, yet they were sometimes reluctant to contribute their data.

Keywords:

  • Bioinformatics;
  • database;
  • molecular biology;
  • molecular evolution;
  • biochemistry;
  • computers;
  • protein sequence