Chapter 11. Sample Sizes

  1. Peter M. Fayers1,2 and
  2. David Machin3,4,5

Published Online: 27 APR 2007

DOI: 10.1002/9780470024522.ch11

Quality of Life: The Assessment, Analysis and Interpretation of Patient-Reported Outcomes, Second edition

Quality of Life: The Assessment, Analysis and Interpretation of Patient-Reported Outcomes, Second edition

How to Cite

Fayers, P. M. and Machin, D. (2007) Sample Sizes, in Quality of Life: The Assessment, Analysis and Interpretation of Patient-Reported Outcomes, Second edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470024522.ch11

Author Information

  1. 1

    University of Aberdeen Medical School, Scotland, UK

  2. 2

    Norwegian University of Science and Technology (NTNU), Trondheim, Norway

  3. 3

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore

  4. 4

    School of Health and Related Research, University of Sheffield, England

  5. 5

    United Kingdom Children's Cancer Study Group (UKCCSG), University of Leicester, England

Publication History

  1. Published Online: 27 APR 2007
  2. Published Print: 2 MAR 2007

ISBN Information

Print ISBN: 9780470024508

Online ISBN: 9780470024522

SEARCH

Keywords:

  • QoL studies designed in case-control format;
  • mean physical functioning (PF) and SF-36 Health Questionnaire;
  • comparing two groups;
  • time-to-event data;
  • range of equivalence or maximum allowable difference;
  • sample size estimate in QoL studies;
  • full HADS scales and HADS outcome;
  • HADS and QoL outcome measure

Summary

This chapter contains sections titled:

  • Introduction

  • Significance tests, p-values and power

  • Estimating sample size

  • Comparing two groups

  • Comparison with a reference population

  • Equivalence studies

  • Choice of sample size method

  • Multiple endpoints

  • Specifying the target difference

  • Sample size estimation is pre-study

  • Attrition

  • Conclusion

  • Further reading