Chapter 18. Clinical Interpretation

  1. Peter M. Fayers1,2 and
  2. David Machin3,4,5

Published Online: 27 APR 2007

DOI: 10.1002/9780470024522.ch18

Quality of Life: The Assessment, Analysis and Interpretation of Patient-Reported Outcomes, Second edition

Quality of Life: The Assessment, Analysis and Interpretation of Patient-Reported Outcomes, Second edition

How to Cite

Fayers, P. M. and Machin, D. (2007) Clinical Interpretation, in Quality of Life: The Assessment, Analysis and Interpretation of Patient-Reported Outcomes, Second edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470024522.ch18

Author Information

  1. 1

    University of Aberdeen Medical School, Scotland, UK

  2. 2

    Norwegian University of Science and Technology (NTNU), Trondheim, Norway

  3. 3

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore

  4. 4

    School of Health and Related Research, University of Sheffield, England

  5. 5

    United Kingdom Children's Cancer Study Group (UKCCSG), University of Leicester, England

Publication History

  1. Published Online: 27 APR 2007
  2. Published Print: 2 MAR 2007

ISBN Information

Print ISBN: 9780470024508

Online ISBN: 9780470024522

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Keywords:

  • population-based reference values;
  • clinical interpretation;
  • statistical significance and power of tests;
  • QoL scores interpretation and population-based reference values;
  • population norms;
  • selective reporting and response shift;
  • minimal clinically important difference;
  • QoL and number needed to treat (NNT)

Summary

This chapter contains sections titled:

  • Introduction

  • Statistical significance

  • Absolute levels and changes over time

  • Threshold values: percentages

  • Population norms

  • Minimal clinically important difference

  • Impact of state of quality of life

  • Changes in relation to life events

  • Effect size

  • Effect sizes and meta-analysis

  • Patient variability

  • Number needed to treat

  • Conclusions

  • Further reading