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Multinuclear Magnetic Resonance Spectroscopic Imaging

Biomedical Spectroscopy

  1. Todd L. Richards

Published Online: 15 SEP 2012

DOI: 10.1002/9780470027318.a0110.pub2

Encyclopedia of Analytical Chemistry

Encyclopedia of Analytical Chemistry

How to Cite

Richards, T. L. 2012. Multinuclear Magnetic Resonance Spectroscopic Imaging . Encyclopedia of Analytical Chemistry. .

Author Information

  1. University of Washington, Seattle, WA, USA

Publication History

  1. Published Online: 15 SEP 2012


Magnetic resonance spectroscopic imaging (MRSI) is a technique for producing spatially resolved maps or images of different chemicals that are found in the body or tissue. These chemicals may be naturally inherent or may be introduced by injection, but they must be detectable by the magnetic resonance (MR) process (i.e. they must have nuclei that have a magnetic moment, and are mobile enough to give a free-induction decay (FID)). The MRSI technique is based on many of the same principles that are used for conventional magnetic resonance imaging (MRI) and also uses much of the same equipment as MRI. This chapter focuses on multinuclear applications of MRSI such as phosphorus-31, carbon-13, fluorine-19, sodium-23, xenon-129, helium-3, and boron-11. The MRSI method is an important technique for noninvasive measurement of biochemical and physiological changes in health and disease.