Standard Article

Diagnostic Hematology

Clinical Chemistry

  1. Joel D. Hubbard

Published Online: 9 JAN 2014

DOI: 10.1002/9780470027318.a0508.pub2

Encyclopedia of Analytical Chemistry

Encyclopedia of Analytical Chemistry

How to Cite

Hubbard, J. D. 2014. Diagnostic Hematology. Encyclopedia of Analytical Chemistry. 1–31.

Author Information

  1. Texas Tech University Health Science Center, Lubbock, TX, USA

  1. Update based on the original article by J. Hubbard, Encyclopedia of Analytical Chemistry, © 2000, John Wiley & Sons, Ltd

Publication History

  1. Published Online: 9 JAN 2014


Hematology, in its pure form, is the study of the red blood cells (RBCs), white blood cells (WBCs), and platelets during normal and pathological conditions. Quantitative and qualitative evaluation and interpretation of the formed elements of the blood require a whole blood sample to be counted using automated cell counters based on electrical impedance or laser light scatter techniques. A wide range of disease types can be encountered, such as hereditary, nutritional, metabolic, traumatic, infections, and inflammatory conditions, and hormonal, immunological, and neoplastic disorders. All these disorders can result in changes to the blood cell profile, which can be used to aid in diagnosis. Most important for the diagnosis of hematological diseases is an in-depth understanding of the different causes of anemia and the pathogenesis of the leukemias.


  • hematology;
  • anemia;
  • leukemia;
  • hemostasis;
  • coagulation