Standard Article

Laboratory Instruments in Clinical Chemistry, Principles of

Clinical Chemistry

  1. Hemant B. Karnik

Published Online: 15 SEP 2006

DOI: 10.1002/9780470027318.a0529

Encyclopedia of Analytical Chemistry

Encyclopedia of Analytical Chemistry

How to Cite

Karnik, H. B. 2006. Laboratory Instruments in Clinical Chemistry, Principles of. Encyclopedia of Analytical Chemistry. .

Author Information

  1. Howard University, Washington D.C., USA

Publication History

  1. Published Online: 15 SEP 2006


In the last 40–45 years, instruments have evolved from simple analyzers that analyze few analytes in an hour to auto analyzers that analyze hundreds of tests in a fraction of an hour. A historical perspective on the evolution of the instruments, with discussion on the basic principles of their operation, along with the advantages and limitations of methodologies, is provided. Information on standardization, quality control and quality assurance in the clinical laboratory is also included. The article concludes with a brief discussion on the future developments in instrumentation. The material presented in this article is meant as a reference. For detailed information the reader is referred to other books and publications.