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Molecular Biological Analyses and Molecular Pathology in Clinical Chemistry

Clinical Chemistry

  1. Y.M. Dennis Lo1,
  2. Ivy H.N. Wong1,
  3. Nancy B.Y. Tsui1,
  4. Ching-Wan Lam2

Published Online: 15 DEC 2009

DOI: 10.1002/9780470027318.a0534.pub2

Encyclopedia of Analytical Chemistry

Encyclopedia of Analytical Chemistry

How to Cite

Dennis Lo, Y., Wong, I. H., Tsui, N. B. and Lam, C.-W. 2009. Molecular Biological Analyses and Molecular Pathology in Clinical Chemistry. Encyclopedia of Analytical Chemistry. .

Author Information

  1. 1

    The Chinese University of Hong Kong, SAR, Hong Kong, China

  2. 2

    The Chinese University of Hong Kong, SAR, Hong Kong, China

Publication History

  1. Published Online: 15 DEC 2009

Abstract

The introduction of powerful methods for the analysis of nucleic acids started a revolution in medicine, opening up a new field of molecular diagnosis. The core technologies of molecular diagnosis involve techniques for the amplification and characterization of nucleic acids. These techniques have enabled the diagnosis of many diseases with unprecedented sensitivity and specificity. As research tools, these methods have increased our understanding of many diseases on a molecular level, with the unraveling of the molecular pathology of many common disorders. The foundation for the rapid and continual development of molecular pathology received a boost from the genome-wide scale analyses of the human genome, such as the Human Genome Project (HGP) and the HapMap Project, which have provided the essential genetic blueprint for future investigations.