Trace Organic Analysis by Gas Chromatography with Quadrupole Mass Spectrometry
Environment: Water and Waste
Published Online: 15 SEP 2006
Copyright © 2000 John Wiley & Sons, Ltd. All rights reserved.
Encyclopedia of Analytical Chemistry
How to Cite
Booth, M. M. and Powell, D. H. 2006. Trace Organic Analysis by Gas Chromatography with Quadrupole Mass Spectrometry. Encyclopedia of Analytical Chemistry. .
- Published Online: 15 SEP 2006
Gas chromatography (GC) with quadrupole mass spectrometry (MS) is one of the most powerful and widely used analytical techniques. This technology combines the high resolving power of GC with the excellent sensitivity and chemical-structure-informing power of quadrupole MS. The combination of these two techniques provides both the selectivity and sensitivity needed for qualitative and quantitative analysis of organic analytes at trace levels in a wide variety of matrices.
This article provides an overview of the development and combination of these two technologies. Types of quadrupole mass spectrometers that are commonly coupled to gas chromatographs are discussed. Both electron ionization (EI) and chemical ionization (CI) are reviewed. Sample preparation methods are discussed for air, water, and solids. The different approaches employed for highly volatile and semi-volatile substances are presented. The use of chemical derivatives to improve sample response and various instrumental analysis considerations are also covered.