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Comparative Genomics Approaches and Technologies

Nucleic Acids Structure and Mapping

  1. Cassandra L. Smith1,2,
  2. Herin Oh1,2,
  3. Dimitrije Stamenović1,2

Published Online: 15 SEP 2012

DOI: 10.1002/9780470027318.a1406.pub2

Encyclopedia of Analytical Chemistry

Encyclopedia of Analytical Chemistry

How to Cite

Smith, C. L., Oh, H. and Stamenović, D. 2012. Comparative Genomics Approaches and Technologies. Encyclopedia of Analytical Chemistry. .

Author Information

  1. 1

    Boston University, Molecular Biotechnology Research Laboratory, Boston, MA, USA

  2. 2

    Boston University, Department of Biomedical Engineering, Boston, MA, USA

Publication History

  1. Published Online: 15 SEP 2012


Comparative molecular approaches used DNA sequencing and less costly alternatives. Today new DNA sequencing methods are dramatically impacting comparative genomics studies and many old approaches are being adapted or enhanced by the ultra-high-throughput sequencing (UHTPS) methods. Even so, the expenses of the newer methods limits their access, while the older methods continue to be improved and applied widely. This article reviews comparative genomics approaches used today but does not review UHTPS methods. A subsequent article by us (Smith and Oh, in preparation) will focus on the impact of the new UHTPS methods on comparative genomics.