Comparative Genomics Approaches and Technologies
Nucleic Acids Structure and Mapping
Published Online: 15 SEP 2012
Copyright © 2000 John Wiley & Sons, Ltd. All rights reserved.
Encyclopedia of Analytical Chemistry
How to Cite
Smith, C. L., Oh, H. and Stamenović, D. 2012. Comparative Genomics Approaches and Technologies. Encyclopedia of Analytical Chemistry. .
- Published Online: 15 SEP 2012
Comparative molecular approaches used DNA sequencing and less costly alternatives. Today new DNA sequencing methods are dramatically impacting comparative genomics studies and many old approaches are being adapted or enhanced by the ultra-high-throughput sequencing (UHTPS) methods. Even so, the expenses of the newer methods limits their access, while the older methods continue to be improved and applied widely. This article reviews comparative genomics approaches used today but does not review UHTPS methods. A subsequent article by us (Smith and Oh, in preparation) will focus on the impact of the new UHTPS methods on comparative genomics.