Nuclear Magnetic Resonance and Nucleic Acid Structures
Nucleic Acids Structure and Mapping
Published Online: 15 SEP 2006
Copyright © 2000 John Wiley & Sons, Ltd. All rights reserved.
Encyclopedia of Analytical Chemistry
How to Cite
Eriksson, M. 2006. Nuclear Magnetic Resonance and Nucleic Acid Structures. Encyclopedia of Analytical Chemistry.
- Published Online: 15 SEP 2006
Nuclear magnetic resonance (NMR) is one of the most important and widely used techniques for studying nucleic acid structure. With modern techniques, including isotope labeling and multidimensional spectroscopy, structures of large molecules – nucleic acids alone or in complexes, for example with proteins or ligands – can be determined. Here is given an overview of experimental NMR methods for nucleic acids studies, complemented by illustrative examples of DNA, RNA and PNA structures.