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Vibrational Spectroscopy in Drug Discovery, Development and Production

Pharmaceuticals and Drugs

  1. Sterling A. Tomellini1,
  2. James W. Finn2

Published Online: 15 SEP 2006

DOI: 10.1002/9780470027318.a1923

Encyclopedia of Analytical Chemistry

Encyclopedia of Analytical Chemistry

How to Cite

Tomellini, S. A. and Finn, J. W. 2006. Vibrational Spectroscopy in Drug Discovery, Development and Production. Encyclopedia of Analytical Chemistry. .

Author Information

  1. 1

    University of New Hampshire, Durham, USA

  2. 2

    Genetics Institute, Andover, USA

Publication History

  1. Published Online: 15 SEP 2006


The area of vibrational spectroscopy encompasses a number of versatile analytical techniques, many of which have been applied successfully to a wide variety of pharmaceutical analyses. While there are many vibrational spectroscopic techniques, some more esoteric or generally applicable than others, this chapter will concentrate on pharmaceutical applications limited to three specific areas: near-infrared (NIR) spectroscopy, mid-infrared (MIR) spectroscopy and Fourier transform Raman spectroscopy (FTRS). The goal of this work is to provide the interested reader with the background necessary to better understand these vibrational spectroscopic techniques and provide an overview of the breadth of applications for these techniques in analyses of pharmaceutical importance. Recently reported applications will be emphasized. The wide variety of sampling methods associated with these techniques will be highlighted throughout. Recent developments which are expected to have an impact on future pharmaceutical applications will also be discussed. Literature and other resources for advanced study are also provided.