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Hyphenated Gas Chromatography

Gas Chromatography

  1. W.M. Coleman III,
  2. Bert M. Gordon

Published Online: 15 SEP 2006

DOI: 10.1002/9780470027318.a5504

Encyclopedia of Analytical Chemistry

Encyclopedia of Analytical Chemistry

How to Cite

Coleman, W. and Gordon, B. M. 2006. Hyphenated Gas Chromatography. Encyclopedia of Analytical Chemistry. .

Author Information

  1. R.J. Reynolds Tobacco Company, Winston-Salem, USA

Publication History

  1. Published Online: 15 SEP 2006


Hyphenated gas chromatography (GC) refers to not only the coupling of a GC to information-rich detectors but also the coupling of the gas chromatograph to automated sample preparation techniques. Examples of information-rich detectors include mass and infrared spectrometers, whereas automated sample preparation techniques include solid-phase microextraction (SPME), large-volume injection (LVI), purge and trap (PT), headspace (HS), and gas chromatographic approaches. The gas chromatographic approach involves the wedding of two gas chromatographs and is commonly referred to as multidimensional gas chromatography (MDGC). The union of the automated sample preparation techniques with MDGC and information-rich detectors affords the capability for quantitative and qualitative analysis of a wide variety of sample matrices for analytes at parts per billion (ppb) concentrations. However, not every hyphenated configuration is worth considering, and careful matching of the hyphenated approaches is essential to obtain the maximum analytical benefits.