High-Resolution Mass Spectrometry and Its Applications
Published Online: 15 SEP 2006
Copyright © 2000 John Wiley & Sons, Ltd. All rights reserved.
Encyclopedia of Analytical Chemistry
How to Cite
Jennings, K. R. 2006. High-Resolution Mass Spectrometry and Its Applications. Encyclopedia of Analytical Chemistry.
- Published Online: 15 SEP 2006
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The modes of operation, strengths and weaknesses of the several different types of mass analyzer currently available for the production of mass spectra of sufficiently high resolution are reviewed. Particular emphasis is placed on the use of mass spectrometry in the detection and identification of samples of biological origin for which its high sensitivity and specificity of information provided are of great importance. This article concludes with a brief review of the uses of high-resolution mass spectrometry, in which the difficulties encountered in working with samples of very high relative molecular mass are discussed and an account is presented of the information to be gained from time-dependent studies of H/D interchange at high resolution.